The evidence is very uncertain about the effect of antihistamines on preventing motion sickness under experimental conditions (standardised mean difference (SMD) 0.32, 95% CI -0.18 to 0.83 2 studies 62 participants) (very low-certainty). There were no studies that clearly assessed the paediatric population.Īntihistamines versus placebo or no treatmentĪntihistamines are probably more effective than placebo at preventing motion sickness symptoms under natural conditions (symptoms prevented: 25% placebo 40% antihistamines) (risk ratio (RR) 1.81, 95% confidence interval (CI) 1.23 to 2.66 3 studies 240 participants) (moderate-certainty). Only the experimentally induced studies measured physiological parameters and only the naturally induced studies evaluated adverse effects. Risk of bias across the studies varied, with mostly low risk for random sequence generation and allocation concealment, and mostly high risk for selective reporting. All the naturally induced studies only evaluated first-generation antihistamines (cinnarizine and dimenhydrinate). Motion sickness was induced naturally in six studies and experimentally in four studies (rotating chair). Studies were conducted across seven countries, with an overall age range of 16 to 55 years. We included nine RCTs (658 participants). ![]() This review is up-to-date to 7 December 2021. There is uncertainty about the effectiveness of antihistamines in preventing motion sickness compared to acupuncture under laboratory conditions. There is uncertainty about the effectiveness of antihistamines in the prevention of motion sickness under natural conditions or laboratory conditions, their effect on stomach movements or their ability to make one drowsy when compared to antiemetics. There is uncertainty about the effectiveness of antihistamines in the prevention of motion sickness or their ability to make one drowsy when compared to scopolamine under natural conditions. ![]() There is uncertainty about whether antihistamines cause blurred vision (not being able to see clearly) or impaired cognition (not being able to think clearly) when compared to placebo. There is uncertainty about whether or not antihistamines are effective at preventing motion sickness, or if they have an effect on gastric tachyarrhythmia (the way the inside of your stomach moves), under experimental conditions (in a laboratory setting) when compared to placebo.Īntihistamines may be more likely to cause sedation (drowsiness) when compared to placebo. The results show that antihistamines are probably more effective than placebo at preventing motion sickness symptoms under natural conditions. We also looked at those that have been given an antihistamines compared with other medicines or other types of non-drug therapy. We looked at studies where people who are known to get motion sickness are given treatment with either an antihistamine or with a placebo (dummy treatment). For all the other findings that were investigated, there is uncertainty about the true effects of antihistamines compared to other drugs and non-drugs, or other side effects and effects on body functions (like heart rate or stomach movements). We did not find any studies that looked at whether or not antihistamines are effective at treating motion sickness once it has already started and there is very little information on their effect in children under the age of 18. We also found that when compared to placebo, antihistamines are more likely to make a person drowsy. We found that antihistamines probably do reduce a person's risk of getting motion sickness symptoms under naturally occurring conditions of motion (like a ship or a plane) when compared to placebo (dummy treatment), in adults who are prone to getting motion sickness. ![]() In this study, we wanted to find out if these drugs actually work for this purpose. Antihistamines are a type of drug that have commonly been given to people to either treat or prevent motion sickness. These symptoms are caused by passive body movement - where your body is moving without you consciously making it move - in response to actual motion (for example, driving in a car or being in a boat), or the illusion of motion when exposed to virtual movement (for example, virtual reality simulations) and moving visual environments (such as looking out of the window of a moving train). Motion sickness, also commonly known as sea sickness or car sickness, is a set of symptoms - usually nausea and vomiting.
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